Tenofovir
| CAS No. | 147127-20-6 | Cat. No. | BCP02416 |
| Name | Tenofovir | ||
| Synonyms | (R)-PMPA;GS-1278;GS 1278;GS1278;TDF;PMPA; | ||
| Formula | C9H14N5O4P | M. Wt | 287.21 |
| Description | Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 μM for wild-type RT, 6 μM for M184V RT and 50 μM for K65R RT. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Reverse Transcriptase HBV HIV | ||
|
Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery
Publications Citing of Biochempartner's Tenofovir(CAS:147127-20-6) |
|
BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates
Publications Citing of Biochempartner's Tenofovir(CAS:147127-20-6) |
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.