TAK-715
| CAS No. | 303162-79-0 | Cat. No. | BCP01965 |
| Name | TAK-715 | ||
| Synonyms | TAK715;TAK 715; | ||
| Formula | C24H21N3OS | M. Wt | 399.52 |
| Description | TAK 715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM. [1] TAK 715 (10 μM) inhibits Wnt-3a-induced hDvl2 phosphorylation and the hDvl2 shift in U2OS-EFC cells. [2] The amide NH of TAK 715 is hydrogen bonded to the main-chain carbonyl of Met109 of p38 alpha. TAK 715 binds relatively high in the ATP pocket, occupying the hydrophobic back pocket, the adenine region and the front pocket of p38 as well as extending to most of the length of the Gly-rich loop. | ||
| Pathways | MAPK Pathway | ||
| Targets | p38 MAPK | ||
Structure
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