Pemetrexed
| CAS No. | 137281-23-3 | Cat. No. | BCP27649 |
| Name | Pemetrexed | ||
| Synonyms | LY231514;LY 231514;LY-231514; | ||
| Formula | C20H21N5O6 | M. Wt | 427.41 |
| Description | Pemetrexed is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DHFR | ||
Structure
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