恩替卡韦一水合物
| CAS号 | 209216-23-9 | 货号 | BCP01930 |
| 中文名 | 恩替卡韦一水合物 | ||
| 英文名 | Entecavir hydrate | ||
| 中文别名 | |||
| 英文别名 | Entecavir monohydrate; | ||
| 分子式 | C12H15N5O3.H2O | 分子量 | 295.29 |
| 生物活性 | Entecavir monohydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir monohydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir monohydrate is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). Entecavir monohydrate is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection. However, Entecavir is not active against HIV. Entecavir cumulative urinary excretion was statistically significant at 45 and 60min. CLR(4°C), CLR(37°C Control) and CLR(37°C Experiment) were 12.6, 27.6 and 36 (ml/min/kg), respectively. CLTS and TR rate (for PEPT2) were 25.3 and 9.4 (ml/min/kg). In vivo, the cumulative urinary excretion of entecavir had statistical significance at 3 and 4h with CLR(Control) and CLR(Experiment) values of 31 and 42 (ml/min/kg), respectively. The CL | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | Reverse Transcriptase HBV | ||
结构式
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