Torin 1
| CAS No. | 1222998-36-8 | Cat. No. | BCP02504 |
| Name | Torin 1 | ||
| Synonyms | Torin1;Torin-1; | ||
| Formula | C35H28F3N5O2 | M. Wt | 607.64 |
| Description | Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Moreover, Torin1 exhibits 1000-fold selectivity for mTOR over PI3K (EC50 = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. Torin1 disrupts mTORC1-dependent phenotypes more completely than rapamycin. Rapamycin-resistant functions of mTORC1 are required for cap-dependent translation.In a recent study, it is reported Torin1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| Targets | DNA PK mTOR | ||
Structure
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