U0126
| CAS No. | 109511-58-2 | Cat. No. | BCP01851 |
| Name | U0126 | ||
| Synonyms | U-0126;U 0126;U0126; | ||
| Formula | C18H16N6S2 | M. Wt | 380.49 |
| Description | U0126-EtOH functionally antagonizes AP- 1 transcriptional activity and blocks the production of a variety of cytokines and metalloproteinases involved in the inflammatory response. U0126-EtOH inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs without effect on IL-2-induced proliferation by down-regulating IL-2 mRNA levels. A recent study shows that U0126-EtOH antagonizes resveratrol-induced apoptosis in castration-resistant human prostate cancer C4-2 cells, inhibits mitochondrial function and shifts cells to aerobic glycolysis independently of MEK. | ||
| Pathways | MAPK Pathway | ||
| Targets | MEK/ERK | ||
Structure
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