Eptifibatide

CAS No.	188627-80-7	Cat. No.	BCP02070
Name	Eptifibatide
Synonyms	148031-34-9;Eptifibatide acetate; Integrilin; Integrelin;
Formula	C35H49N11O9S2	M. Wt	831.96

Description	Eptifibatide is a potent glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; Kd = 120 nM) that inhibits platelet aggregation. Eptifibatide prevents binding of the adhesion proteins fibrinogen and von Willebrand factor to GPIIb/IIIa on the surface of activated platelets to prevent aggregation and thrombus formation. It inhibits ADP-induced citrated blood aggregation (IC50 = 0.11-0.22 μg/ml) in vitro and in vivo (IC50 = 52 μg/ml in porcine plasma). Formulations containing eptifibatide have been used to reduce risk of thrombolysis in myocardial infarction in patients undergoing percutaneous coronary intervention.
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	Integrin

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