Geldanamycin
| CAS No. | 30562-34-6 | Cat. No. | BCP02403 |
| Name | Geldanamycin | ||
| Synonyms | BRN1633093; | ||
| Formula | C29H40N2O9 | M. Wt | 560.64 |
| Description | Geldanamycin binds in the ATP-binding site in the N-terminus domain of Hsp90s (residues 1-220). Geldanamycin inhibits the ATPase activity of Hsp90 in a dose-dependent manner.Geldanamycin causes a dose-dependent G2 arrest and reversible inhibiton o f entry into the S phase in A2780 human ovarian cell line. This inhibition is accompanied by p53 increase and finally demonstrated to be p53 dependent.Geldanamycin causes polyubiquitination and proteasomal degradation of the p185 receptor protein-tyrosin kinase and shows a IC50 with 70 nM.Geldanamycin is a typical anti-tumor reagent, shows a mean GI50 with 0.18 μM against the panel of 60 human tumor cell lines. | ||
| Pathways | Protease/Metabolic Enzyme Cell Cycle/DNA Damage | ||
| Targets | HSP | ||
Structure
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