Mifepristone
| CAS No. | 84371-65-3 | Cat. No. | BCP02145 |
| Name | Mifepristone | ||
| Synonyms | RU-486;RU 486;RU486;RU-38486;RU 38486;RU38486;Mifegyne;Mifeprex; | ||
| Formula | C29H35NO2 | M. Wt | 429.59 |
| Description | Mifepristone inhibit corticoid-induced transcription from a glucocorticoid response element (GRE)-linked luciferase reporter gene in the human lung carcinoma cell line A549. Moreover, Mifepristone also blocks progesterone induction of alkaline phosphatase activity in the human breast cancer cell line T47D. Mifepristone inhibits ovarian cancer cell growth of SK-OV-3 and OV2008 with IC50 of 6.25 μM and 6.91 μM, respectively. A recent study shows that Mifepristone induces caspase-1 over expression both in differentiated and undifferentiated caspase-1-embryonic stem cells. | ||
| Pathways | Hormone Pathay GPCR/G Protein | ||
| Targets | Glucocorticoid Receptor Progesterone Receptor | ||
Structure
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