GSK461364
| CAS号 | 929095-18-1 | 货号 | BCP01720 |
| 中文名 | GSK461364 | ||
| 英文名 | GSK461364 | ||
| 中文别名 | |||
| 英文别名 | GSK-461364;GSK 461364; | ||
| 分子式 | C27H28F3N5O2S | 分子量 | 543.6 |
| 生物活性 | GSK461364 inhibits cancer cell line proliferation from multiple origins with minimal toxicity in nondividing human cells. [1] RNA silencing of WT p53 increases the antiproliferative activity of GSK461364. As many cancer therapies tend to be more effective in p53 WT patients, the higher sensitivity of p53-deficient tumors toward GSK461364 could potentially offer an opportunity to treat tumors that are refractory to other chemotherapies as well as early line therapy for these genotypes. GSK461364 i | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | PLK | ||
结构式
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