3-Methyladenine
| CAS No. | 5142-23-4 | Cat. No. | BCP02452 |
| Name | 3-Methyladenine | ||
| Synonyms | 3MA;NSC 66389; NSC-66389; NSC66389;3-methyl-adenin;3-Methyladenine;Adenine, 3-methyl-;3-Methyl-3H-purin-6-amine;3-Methyl-6-am; 6-Amino-3-methylpurine; | ||
| Formula | C6H7N5 | M. Wt | 149.15 |
| Description | Autophagy Inhibitor, 3-MA is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. Autophagy Inhibitor, 3-MA is a class III PI 3-kinase inhibitor that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 and Wortmannin, in that treatment of cells with 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. | ||
| Pathways | Others Pathway PI3K/Akt/mTOR | ||
| Targets | Autophagy PI3K | ||
Structure
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