LY2811376
| CAS No. | 1194044-20-6 | Cat. No. | BCP02221 |
| Name | LY2811376 | ||
| Synonyms | LY 2811376;LY-2811376; | ||
| Formula | C15H14F2N4S | M. Wt | 320.36 |
| Description | LY2811376 demonstrates concentration-dependent inhibition of hBACE1 with an IC50 of 239 and 249 nM against a small synthetic peptide or a larger chimeric protein substrate, respectively. LY2811376 treatment yields a concentration-dependent decrease in Aβ secretion in APP-overexpressing HEK293 cells. LY2811376 inhibits Aβ secretion with EC50 of ~100 nM in primary neuronal cultures of PDAPP transgenic mouse. | ||
| Pathways | Neuro Signaling Pathway | ||
| Targets | Beta secretase | ||
Structure
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