LY2811376
CAS号 | 1194044-20-6 | 货号 | BCP02221 |
中文名 | LY2811376 | ||
英文名 | LY2811376 | ||
中文别名 | |||
英文别名 | LY 2811376;LY-2811376; | ||
分子式 | C15H14F2N4S | 分子量 | 320.36 |
生物活性 | LY2811376 demonstrates concentration-dependent inhibition of hBACE1 with an IC50 of 239 and 249 nM against a small synthetic peptide or a larger chimeric protein substrate, respectively. LY2811376 treatment yields a concentration-dependent decrease in Aβ secretion in APP-overexpressing HEK293 cells. LY2811376 inhibits Aβ secretion with EC50 of ~100 nM in primary neuronal cultures of PDAPP transgenic mouse. | ||
信号通路 | Neuro Signaling Pathway | ||
靶 点 | Beta secretase |
结构式
![](https://img.biochemsafebuy.com/uploads/img/1194044-20-6_BCP02221.png)
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