PH-797804
| CAS No. | 586379-66-0 | Cat. No. | BCP02266 |
| Name | PH-797804 | ||
| Synonyms | PH797804;PH 797804; | ||
| Formula | C22H19BrF2N2O3 | M. Wt | 477.3 |
| Description | PH-797804 blocks LPS-induced TNF-α production and p38 kinase activity in the human monocytic U937 cell line, with comparable IC50 of 5.9 nM and 1.1 nM. PH-797804 has no inhibitory effect on either the JNK pathway (c-Jun phosphorylation) or ERK pathway (ERK phosphorylation) in U937 cells at concentrations up to 1 μM. PH-797804 inhibits RANKL- and M-CSF-induced osteoclast formation in a concentration-dependent manner, with IC50 of 3 nM in primary rat bone marrow cells.IC50 values for PH-797804 against the following targets have been determined to be greater than 200 μM (unless specified): CDK2, ERK2, IKK1, IKK2, IKKi, MAPKAP2, MAPKAP3, MKK7 (>100 μM), MNK, MSK (>164 μM), PRAK, RSK2, and TBK1, which means the activity of PH-797804 is specific. | ||
| Pathways | MAPK Pathway | ||
| Targets | p38 MAPK | ||
Structure
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