Laropiprant
| CAS No. | 571170-77-9 | Cat. No. | BCP02136 |
| Name | Laropiprant | ||
| Synonyms | Cardaptive;MK 0524;MK-0524;MK0524; | ||
| Formula | C21H19ClFNO4S | M. Wt | 435.9 |
| Description | Laropiprant(Cardaptive; MK 0524) inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Prostaglandin Receptor | ||
Structure
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