CHIR99021
| CAS No. | 252917-06-9 | Cat. No. | BCP01901 |
| Name | CHIR99021 | ||
| Synonyms | CT99021;CHIR-99021;CHIR 99021;CT-99021; CHIR-73911; CHIR73911; CHIR 73911; GSK 3 inhibitor XVI; GSK 3IXV;CHIR-911; CHIR911; CHIR 911; | ||
| Formula | C22H18Cl2N8 | M. Wt | 465.34 |
| Description | CHIR-99021, also known as CT99021, is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. | ||
| Pathways | Wnt/Stem Cell PI3K/Akt/mTOR | ||
| Targets | GSK3 | ||
Structure
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