PF-562271
| CAS No. | 717907-75-0 | Cat. No. | BCP01852 |
| Name | PF-562271 | ||
| Synonyms | PF562271;PF00562271; | ||
| Formula | C21H20F3N7O3S | M. Wt | 507.49 |
| Description | PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels. | ||
| Related Products | 939791-38-5（PF-562271 benzenesulfonate） 939791-41-0（PF-562271 HCl） | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FAK | ||
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Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer
Publications Citing of Biochempartner's PF-562271(CAS:717907-75-0) |
Structure
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