CX-3543
| CAS No. | 865311-47-3 | Cat. No. | BCP01793 |
| Name | CX-3543 | ||
| Synonyms | Quarfloxin;CX3543;CX 3543; Itarnafloxin; Quarfloxacin; | ||
| Formula | C35H33FN6O3 | M. Wt | 604.67 |
| Description | CX-3543 is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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