3-Deazaneplanocin A
| CAS No. | 102052-95-9 | Cat. No. | BCP02349 |
| Name | 3-Deazaneplanocin A | ||
| Synonyms | DZNep;3-Deazaneplanocin; NSC 617989; | ||
| Formula | C12H14N4O3 | M. Wt | 262.26 |
| Description | 3-deazaneplanocin A, also known as DZNep, is a well-known histone methyltransferase inhibitor, which disrupts polycomb-repressive complex 2 (PRC2), and induces apoptosis, while inhibiting proliferation and metastasis, in cancer cells, including acute myeloid leukemia, breast cancer and glioblastoma. DZNep is a promising therapeutic agent for ovarian cancer cells, with potential to inhibit proliferation, induce apoptosis and decrease migration. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Methyltransferase Epigenetic Reader Domain | ||
Structure
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