PD-173955
| CAS No. | 260415-63-2 | Cat. No. | BCP02294 |
| Name | PD-173955 | ||
| Synonyms | PD 173955;PD173955; | ||
| Formula | C21H16Cl2N4OS | M. Wt | 443.35 |
| Description | PD173955 potently inhibits Bcr-Abl-dependent cell growth with IC50 of 2-35 nM in Bcr-Abl-positive cell lines, about 100- to 200-fold more sensitive than in Bcr-Abl-negative cell lines. PD173955 also inhibits kit ligand-dependent proliferation of M07e cells with IC50 of 40 nM, by inhibition of kit ligand-dependent c-kit autophosphorylation. In addition, PD173955, as a Src inhibitor, potently inhibits mitotic progression during early mitosis in cells of all types and induces varying degrees of apoptotic cell death. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Src/Bcr Abl | ||
Structure
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