Doxorubicin HCl

CAS No.	25316-40-9	Cat. No.	BCP02082
Name	Doxorubicin HCl
Synonyms	Dox HCl;Adriamycin;Doxorubicin;Doxorubicin hydrochloride; Hydroxydaunorubicin hydrochloride;
Formula	C27H29NO11.HCl	M. Wt	579.99

Description	Doxorubicin, an antibiotic anthracycline, is commonly considered to exert its anti-tumor activity at two fundamental levels, altering DNA and producing free radicals to trigger apoptosis of cancer cells through DNA damage. Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. Pre-treatment with GSNO (nitrosoglutathione) suppresses the resistance in the doxorubicin-resistant breast cancer cell line MCF7/Dx, accompanied by enhanced protein glutathionylation and acc
Pathways	Cell Cycle/DNA Damage Others Pathway
Targets	Topoisomerase ADC Related

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