PF3845
| CAS号 | 1196109-52-0 | 货号 | BCP02317 |
| 中文名 | PF3845 | ||
| 英文名 | PF3845 | ||
| 中文别名 | |||
| 英文别名 | PF-3845;PF 3845; | ||
| 分子式 | C24H23F3N4O2 | 分子量 | 456.46 |
| 生物活性 | PF-3845 treated mice (10 mg/kg, i.p.) shows rapid and complete inactivation of FAAH in the brain, as judged by competitive activity-based protein profiling (ABPP) with the serine hydrolase-directed probe fluorophosphonate (FP)-rhodamine. PF-3845 shows a long duration of action up to 24 hour. PF-3845-treated mice also shows dramatic (>10-fold) elevation in brain levels of AEA and other NAEs (N-pamitoyl ethanolamine [PEA] and N-oleoyl ethanolamine [OEA]). FAAH is AEA-degrading enzyme fatty acid amide hydrolase. PF-3845 (1–30 mg/kg, oral administration [p.o.]) causes a dose dependent inhibition of mechanical allodynia with a minimum effective dose (MED) of 3 mg/kg (rats are analyzed at 4 hour post dosing with PF-3845). At higher doses (10 and 30 mg/kg), PF-3845 inhibits pain responses to an equivalent, if not greater, degree than the nonsteroidal anti-inflammatory drug naproxen (10mg/kg, p.o.).PF-3845 (10 mg/kg, i.p.) significantly reverses LPS-induced tactile allodynia, but doesn't modif | ||
| 信号通路 | Protease/Metabolic Enzyme Neuro Signaling Pathway | ||
| 靶 点 | FAAH | ||
结构式
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