PF-3716556
| CAS No. | 928774-43-0 | Cat. No. | BCP02331 |
| Name | PF-3716556 | ||
| Synonyms | PF3716556;PF-03716556;PF 03716556; | ||
| Formula | C22H26N4O3 | M. Wt | 394.47 |
| Description | PF-03716556 is a potent, and selective acid pump antagonist with pIC50 of about of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively. PF-03716556 is used for the treatment of gastroesophageal reflux disease. PF-03716556 is highly selective for H+, K+-ATPase in vitro, displays no activity at Na+, K+-ATPase. PF-03716556 has no species differences among the porcine, canine and human enzymes. PF-03716556 has a competitive and reversible mode of action. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | Potassium Channel ATPase | ||
Structure
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