伐诺司林二盐酸盐
| CAS号 | 67469-78-7 | 货号 | BCP02306 |
| 中文名 | 伐诺司林二盐酸盐 | ||
| 英文名 | Vanoxerine dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | GBR-12909 dihydrochloride; GBR12909 dihydrochloride; GBR 12909 dihydrochloride; | ||
| 分子式 | C28H32F2N2O.2(HCl) | 分子量 | 523.49 |
| 生物活性 | GBR-12909 is a potent dopamine transport blocker studied extensively in rats. By inhibiting DAT function, GBR-12909 was able to induce a bipolar disorder mania-like phenotypes in mice. Also shown to cause postnatal changes to produce useful ADHD animal models. GBR-12909 caused an increase in core body temperature when administered to serotonin transporter knockout mice. Reportedly mimics cocaine-mediated enhancement of Tat neurotoxicity in rat midbrain primary cell cultures. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | Dopamine Transporter | ||
结构式
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