Quisinostat
| CAS No. | 875320-29-9 | Cat. No. | BCP01811 |
| Name | Quisinostat | ||
| Synonyms | JNJ-26481585;JNJ 26481585;JNJ26481585; | ||
| Formula | C21H26N6O2 | M. Wt | 394.48 |
| Description | JNJ-26481585 exhibits broad spectrum antiproliferative activity in solid and hematologic cancer cell lines, such as all lung, breast, colon, prostate, brain, and ovarian tumor cell lines, with IC50 ranging from 3.1-246 nM, which is more potent than vorinostat, R306465, panobinostat, CRA-24781, or mocetinostat in various human cancer cell lines tested.A recent study shows that JNJ-26481585 promotes myeloma cell death at low nanomolar concentrations by resulting in Mcl-1 depletion and Hsp72 induction. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | HDAC | ||
Structure
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