CX-4945
| CAS号 | 1009820-21-6 | 货号 | BCP02399 |
| 中文名 | CX-4945 | ||
| 英文名 | CX-4945 | ||
| 中文别名 | |||
| 英文别名 | Silmitasertib;CX 4945;CX4945; | ||
| 分子式 | C19H12ClN3O2 | 分子量 | 349.77 |
| 生物活性 | Silmitasertib is an orally bioavailable small-molecule inhibitor of the enzyme casein kinase II (CK2), with potential antineoplastic, anti-viral and immunomodulatory activities. Upon oral administration, silmitasertib selectively binds to and inhibits the activity of CK2. This may inhibit proliferation of CK2-expressing tumor cells, and may also inhibit the replication of severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). In addition, this may restore normal host cell cytokine regulation, prevent cytokine storm and suppress the hyperactivation of the innate immune system. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. CK2 regulates a diverse array of pro-survival cellular processes including epidermal growth factor receptor (EGFR) signaling, PI3K/AKT/mTOR signaling, hedgehog (Hh) signaling, Hsp90 machinery, hypoxia, and interleukin (IL)-6 expression. CK2 also regulates the activity of XRCC1 and MDC1, two mediator/adaptor proteins that are essential for DNA repair. CK2 is upregulated by SARS-COV-2 and is associated with SARS-COV-2 viral replication and the development of cytokine storm. | ||
| 信号通路 | Cell Cycle/DNA Damage Wnt/Stem Cell | ||
| 靶 点 | Casein Kinase | ||
结构式
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