A-769662
| CAS No. | 844499-71-4 | Cat. No. | BCP01873 |
| Name | A-769662 | ||
| Synonyms | A 769662;A769662; | ||
| Formula | C20H12N2O3S | M. Wt | 360.39 |
| Description | A 769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs. Activates autophagy. | ||
| Pathways | PI3K/Akt/mTOR Epigenetics | ||
| Targets | AMPK | ||
Structure
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