Elvitegravir
| CAS No. | 697761-98-1 | Cat. No. | BCP01801 |
| Name | Elvitegravir | ||
| Synonyms | GS-9137; GS 9137; GS9137; EVG; JTK 303; JTK-303; JTK303;D06677; | ||
| Formula | C23H23ClFNO5 | M. Wt | 447.88 |
| Description | Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome and thereby blocks the formation of the HIV-1 provirus and resulting propagation of the viral infection. Although available as a single dose tablet, elvitegravir must be used in combination with an HIV protease inhibitor coadministered with ritonavir and another antiretroviral drug. Elvitegravir was first licensed from Japan Tobacco in 2008 and developed by Gilead Sciences. It was FDA approved on August 27, 2012. On September 24, 2014, the FDA approved the single pill form of elvitegravir. | ||
| Pathways | Protease/Metabolic Enzyme Microbiology/Virology | ||
| Targets | Integrase HIV | ||
Structure
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