AT7867
| CAS号 | 857531-00-1 | 货号 | BCP02406 |
| 中文名 | AT7867 | ||
| 英文名 | AT7867 | ||
| 中文别名 | |||
| 英文别名 | AT-7867;AT 7867; | ||
| 分子式 | C20H20ClN3 | 分子量 | 337.85 |
| 生物活性 | AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50 of 20 nM and 85 nM, respectively. AT7867 shows ATP-competitive activity to Akt2 with Ki of 18 nM. AT7867 exhibits antiproliferation in cell lines with PTEN or PIK3CA mutations and shows great potent to MES-SA, MDA-MB-468, MCF-7, HCT116 and HT29 with IC50 of 0.94 μM, 2.26 μM, 1.86 μM, 1.76 μM and 3.04 μM, respectively. AT7867 also suppresses the cell growth of U87MG, PC-3 and DU145 cells with IC50 of 8.22 μM, 10.37 μM and 11.86 μM, respectively. AT7867 suppresses Akt activity by inhibiting phosphorylation of GSK-3β in human tumor cells with IC50 of 2-4 μM. AT7867 also induces the phosphorylation of the following Akt direct substrates including proapoptotic transcription factors FKHR (FoxO1a), FKHRL1 (FoxO3a) and the downstream target S6RP in U87MG cells. | ||
| 信号通路 | GPCR/G Protein Wnt/Stem Cell PI3K/Akt/mTOR MAPK Pathway | ||
| 靶 点 | PKA RSK AKT | ||
结构式
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