Aprepitant
| CAS No. | 170729-80-3 | Cat. No. | BCP02095 |
| Name | Aprepitant | ||
| Synonyms | MK-0869;MK 0869;MK0869; ONO7436; ONO-7436; ONO 7436; L754030; L-754030; L 754030; MK-869;MK-0517; | ||
| Formula | C23H21F7N4O3 | M. Wt | 534.43 |
| Description | Aprepitant is a small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. | ||
| Pathways | GPCR/G Protein | ||
| Targets | NK Receptor | ||
Structure
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