AG-490
| CAS No. | 133550-30-8 | Cat. No. | BCP01722 |
| Name | AG-490 | ||
| Synonyms | AG 490;Tyrphostin B42;AG490;Tyrphostin AG490; | ||
| Formula | C17H14N2O3 | M. Wt | 294.3 |
| Description | AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell | ||
| Targets | Stat EGFR | ||
Structure
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