星孢菌素
| CAS号 | 62996-74-1 | 货号 | BCP27724 |
| 中文名 | 星孢菌素 | ||
| 英文名 | Staurosporine | ||
| 中文别名 | |||
| 英文别名 | AM-2282; AM2282; AM 2282; STS; Antibiotic 230; CGP 41251; CGP41251; CGP-41251; CCRIS 3272; Staurosporine; | ||
| 分子式 | C28H26N4O3 | 分子量 | 466.53 |
| 生物活性 | Staurosporine, also known as antibiotic AM-2282 or STS, is a potent, non-selective inhibitor of protein kinases, including protein kinase C with promising anti-cancer activity. Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity. | ||
| 信号通路 | GPCR/G Protein Wnt/Stem Cell | ||
| 靶 点 | PKA | ||
结构式
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