AZ3146
| CAS号 | 1124329-14-1 | 货号 | BCP02545 |
| 中文名 | AZ3146 | ||
| 英文名 | AZ3146 | ||
| 中文别名 | |||
| 英文别名 | AZ 3146;AZ-3146; | ||
| 分子式 | C24H32N6O3 | 分子量 | 452.55 |
| 生物活性 | AZ3146 also inhibits FAK, JNK1, JNK2 and Kit. AZ3146 significantly inhibits phosphorylation of Mps1 in cells. Mitotic-specific phospho forms of aurora B and BubR1 are not affected by AZ3146. AZ3146 does not inhibit Cdk1 or aurora B in mitotic cells. HeLa cells treated with nocodazole and 2 μM AZ3146 only delay mitosis briefly and then rereplicate their genomes, indicating that AZ3146 overrides the SAC. AZ3146 also inhibits an already established SAC signal, as after release from a nocodazole block, AZ3146 dramatically accelerates mitotic exit.During an otherwise unperturbed mitosis, AZ3146 reduces the time to complete mitosis from 90 minutes in controls to 32 minutes. Strikingly, ~90% of AZ3146-treated HeLa cells undergo abnormal mitoses, although ~50% enter anaphase without aligning all of their chromosomes, and ~30% exit mitosis without undergoing obvious chromosome segregation. AZ3146 has a dramatic effect on kinetochore localization of Mad2, reducing its levels to ~15%, but its eff | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Mps1 | ||
结构式
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