Triptolide
| CAS No. | 38748-32-2 | Cat. No. | BCP01915 |
| Name | Triptolide | ||
| Synonyms | PG490;PG 490;PG-490; NSC163062; NSC-163062; NSC 163062; | ||
| Formula | C20H24O6 | M. Wt | 360.41 |
| Description | Triptolide is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties. Triptolide is shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. Triptolide inhibits the proliferation and colony formation of tumor cells at extremely low concentrations (2–10 ng/mL). Triptolide has an inhibitory activity on breast, stomach and leukemia cell line HL-60 cells. Triptolide induces apoptosis in tumor cells by blocking NF-κB activation and sensitizing tumor cells for TNF-&alpha induced programmed cell death. | ||
| Pathways | Protease/Metabolic Enzyme Cell Cycle/DNA Damage Apoptosis Pathway NFκB | ||
| Targets | TAK1 Mdm2 HSP | ||
Structure
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