贝曲西班
| CAS号 | 330942-05-7 | 货号 | BCP01903 |
| 中文名 | 贝曲西班 | ||
| 英文名 | Betrixaban | ||
| 中文别名 | |||
| 英文别名 | PRT-054021;PRT 054021;PRT054021; MK-4448; MK 4448; MK4448; PRT-021; PRT 021; PRT021; MLN-1021; MLN 1021; MLN1021; | ||
| 分子式 | C23H22ClN5O3 | 分子量 | 451.91 |
| 生物活性 | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa. It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity. Betrixaban, now developed by Portola Pharmaceuticals Inc., is prescribed as a venous thromboembolism (VTE) prophylactic for adult patients with moderate to severe restricted motility or with other risks for VTE. VTE can be manifested as deep vein thrombosis or pulmonary embolism and it is a leading cause of preventable death in hospitalized patients. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Factor Xa | ||
结构式
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