OSI-930
| CAS No. | 728033-96-3 | Cat. No. | BCP02118 |
| Name | OSI-930 | ||
| Synonyms | OSI930;OSI 930; | ||
| Formula | C22H16F3N3O2S | M. Wt | 443.44 |
| Description | OSI-930 inhibits the cell proliferation in the HMC-1 cell line with IC50 of 14 nM without significant effect on growth of the COLO-205 cell line that does not express a constitutively active mutant receptor tyrosine kinase. Moreover, OSI-930 also induces apoptosis in HMC-1 cell line with EC50 of 34 nM.A recent study shows that OSI-930 inactivates purified, recombinant cytochrome P450 (P450) 3A4 with a Ki of 24 μM in a time- and concentration-dependent mode. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | VEGFR c Kit cFMS | ||
Structure
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