Panobinostat

CAS No.	404950-80-7	Cat. No.	BCP01816
Name	Panobinostat
Synonyms	LBH589; LBH 589; LBH-589; NVP-LBH589; NVP-LBH-589; NVP-LBH 589;
Formula	C21H23N3O2	M. Wt	349.43

Description	Panobinostat, also known as NVP LBH-589 or LBH-589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. On 2/23/2015, it received FDA accelerated approval for use in patients with multiple myeloma who had received at least 2 previous treatments, including bortezomib and an immunomodulatory agent.
Pathways	Cell Cycle/DNA Damage Epigenetics
Targets	HDAC

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