Tenovin-6
| CAS No. | 1011557-82-6 | Cat. No. | BCP08547 |
| Name | Tenovin-6 | ||
| Synonyms | Tenovin6 ;Tenovin 6;Tnv-6; Tnv6;Tnv 6; | ||
| Formula | C25H34N4O2S | M. Wt | 454.6 |
| Description | Tenovin-6, also known as Tnv-6, is a bioactive small molecule SIRT2 inhibitor with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Tnv-6 causes non-genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to Tnv-6 did not induce cellular apoptosis or p53-pathway activity. Transcriptomic profiling identified a gene program influenced by Tnv-6 that included autophagy-lysosomal pathway genes. | ||
| Pathways | Cell Cycle/DNA Damage Apoptosis Pathway Epigenetics | ||
| Targets | Sirtuin HDAC p53 | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.