UNC0646

  • Chemical Properties
CAS No. 1320288-17-2 Cat. No. BCP08634
Name UNC0646
Synonyms UNC0646;UNC 0646;
Formula C36H59N7O2 M. Wt 621.9
  • Biological Activity
Description Potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). Selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.
Pathways Epigenetics 
Targets Histone Methyltransferase 

Structure

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