阿迪普隆

化学数据

CAS号	924416-43-3	货号	BCP08895
中文名	阿迪普隆
英文名	AdipoRon
中文别名
英文别名	SC-396658;
分子式	C27H28N2O3	分子量	428.52

用途

生物活性	AdipoRon is a potent and selective adiponectin receptor agonist. AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon may be a promising therapeutic approach for the treatment of obesity-related disease.

生物活性

AdipoRon is a potent and selective adiponectin receptor agonist. AdipoRon attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet. AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon may be a promising therapeutic approach for the treatment of obesity-related disease.

结构式

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