Topotecan
| CAS No. | 123948-87-8 | Cat. No. | BCP08995 |
| Name | Topotecan | ||
| Synonyms | NSC 609699 NSC-609699 NSC609699; SKF S104864A; | ||
| Formula | C23H23N3O5 | M. Wt | 421.45 |
| Description | Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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