GSK2656157
| CAS No. | 1337532-29-2 | Cat. No. | BCP09007 |
| Name | GSK2656157 | ||
| Synonyms | GSK 2656157; GSK-2656157; | ||
| Formula | C23H21FN6O | M. Wt | 416.45 |
| Description | GSK2656157 is is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases. GSK2656157 inhibits PERK activity in cells with an IC50 in the range of 10-30 nM by inhibition of stress-induced PERK autophosphorylation, eIF2α substrate phosphorylation, together with corresponding decreases in ATF4 and CHOP proteins in multiple cell lines. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PERK | ||
Structure
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