IB-MECA

  • Chemical Properties
CAS No. 152918-18-8 Cat. No. BCP09014
Name IB-MECA
Synonyms CF101; CF-101; CF 101; ALB-7208; ALB 7208; ALB7208; IB MECA; Piclidenoson;
Formula C18H19IN6O4 M. Wt 510.29
  • Biological Activity
Description IB-MECA, also known as CF101, is a specific agonist to the A3 adenosine receptor, which inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. CF101 has been shown to downregulate PKB/Akt and NF-κB protein expression level. CF101 potentiates the cytotoxic effect of 5-FU, thus preventing drug resistance. The myeloprotective effect of CF101 suggests its development as an add-on treatment to 5-FU.
Pathways GPCR/G Protein 
Targets Adenosine Receptor 

Structure

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