BX 513 hydrochloride
| CAS No. | 1216540-18-9 | Cat. No. | BCP27909 |
| Name | BX 513 hydrochloride | ||
| Synonyms | VUF 2274;VUF2274; BX513 hydrochloride; BX-513 hydrochloride; | ||
| Formula | C28H29ClN2O.HCl | M. Wt | 481.46 |
| Description | BX-513 hydrochloride is a selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor. | ||
| Pathways | GPCR/G Protein | ||
| Targets | CCR | ||
Structure
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