UCB 35625
| CAS No. | 301648-08-8 | Cat. No. | BCP27911 |
| Name | UCB 35625 | ||
| Synonyms | UCB-35625 ; UCB35625；J-113863；J 113863；J113863; | ||
| Formula | C30H37Cl2IN2O2 | M. Wt | 655.44 |
| Description | UCB35625 is a potent chemokine CKR-1 (CCR1) and CKR-3 (CCR3) receptor antagonist. It inhibits MIP-1α-induced chemotaxis in CKR-1 transfectants (IC50 = 9.57 nM) and eotaxin-induced chemotaxis in CKR-3 transfectants (IC50 = 93.8 nM). UCB 35625 also antagonizes CKR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM). | ||
| Pathways | GPCR/G Protein | ||
| Targets | CCR | ||
Structure
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