Colchicine

CAS No.	64-86-8	Cat. No.	BCP09065
Name	Colchicine
Synonyms	Colchicina; Colchicin; Condylon; Colsaloid; Colchicinum;
Formula	C22H25NO6	M. Wt	399.44

Description	Colchicine is a medication most commonly used to treat gout. Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, so colchicine effectively functions as a "mitotic poison" or spindle poison. The mitosis-inhibiting function of colchicine has been of great use in the study of cellular genetics. To see the chromosomes of a cell under a light microscope, it is important that they be viewed near the point in the cell cycle in which they are most dense. This occurs near the middle of mitosis (specifically metaphase), so mitosis must be stopped before it completes.
Pathways	Cell Cycle/DNA Damage
Targets	Microtubule

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