A77 1726

CAS No.	163451-81-8	Cat. No.	BCP09095
Name	A77 1726
Synonyms	Teriflunomide; A-771726; SU 20; HMR 1726; Flucyamide;
Formula	C12H9F3N2O2	M. Wt	270.21

Description	A77 1726, also known as Teriflunomide, is the active metabolite of leflunomide. This compound has demonstrated anti-inflammatory, antiproliferative and immunosuppressive effects. A77 1726 has been shown to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, dihydroorotate dehydrogenase (DHODH), and blocks TNF-dependent nuclear factor-kappa B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thought to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound.
Pathways	Others Pathway
Targets	Others

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.

For product details of different batches, please contact our Customer

Products are for research use only and not for human use. We do not sell to patients.