R306465
| CAS No. | 604769-01-9 | Cat. No. | BCP09101 |
| Name | R306465 | ||
| Synonyms | R-306465;R 306465;JNJ16241199;JNJ-16241199;JNJ 16241199; | ||
| Formula | C19H19N5O4S | M. Wt | 413.45026 |
| Description | R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro. R306465 potently inhibited cell proliferation of all main solid tumour indications, including ovarian, lung, colon, breast and prostate cancer cell lines, with IC50 values ranging from 30 to 300 nM. The high activity of R306465 in cell-based assays and in vivo after oral administration makes R306465 a promising novel antitumoral agent with potential applicability in a broad spectrum of human malignancies. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | HDAC | ||
Structure
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