Salirasib
| CAS No. | 162520-00-5 | Cat. No. | BCP27978 |
| Name | Salirasib | ||
| Synonyms | S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS; | ||
| Formula | C22H30O2S | M. Wt | 358.54 |
| Description | Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
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