HS-173
| CAS No. | 1276110-06-5 | Cat. No. | BCP09225 |
| Name | HS-173 | ||
| Synonyms | HS173; HS 173; | ||
| Formula | C21H18N4O4S | M. Wt | 422.46 |
| Description | HS-173 is a potent PI3Kα inhibitor with potential anticancer activity. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
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